Programme

Monday, 16 June 2025

14:00 - Check-in and registration (reception hotel)

Session 1: Setting the scene

18:00 - Welcome opening, Folkert Van Werven, Jane Mellor, Dom Helmlinger

18:05 - Message from FEBS, Tamás Arányi, HUN-REN Research Center for Natural Sciences

18:20 - Single-molecule microscopy reveals unexpected features of RNApII transcription
Stephen Buratowski, HMS (abstract 01)

19:10 - End of session

19:15 - Welcome Cocktails (Bar Dali)

19:45 – Dinner (restaurant)

Tuesday, 17 June 2025

from 8:00 – Breakfast (restaurant)

Session 2 (chair Jane Mellor)

09:00 - EMBO YIP lecture: Understanding transcription: one molecule at a time
Tineke Lenstra, NKI (25’ + 5’, abstract 02)

09:30 - Cryo-EM structures reveal the molecular mechanisms of a co-transcriptional histone modification, James Walshe, MPI (abstract 03)

09:50 - The molecular mechanisms of RNA polymerase II elongation stimulation by IWS1
Kristina Zumer, MPI (15’ + 5’, abstract 04)

10:10 - Studying gene expression dynamics with synthetic promoter sequences
Serge Pelet, Université de Lausanne (15’ + 5’, abstract 05)

10:30 - Coffee break + group photo

11:00 - Dissecting co-transcriptional repression mechanisms at Arabidopsis FLC using modelling and experiments, Martin Howard, John Innes Centre (25’ + 5’, abstract 06)

11:30 - Determinants of transcriptional regulation by the SAGA and TIP60 co-activator complexes
Dune Noly, CRBM, Université de Montpellier (15’ + 5’, abstract 07)

11:50 - Direct observation of transcription factor association and dissociation dynamics at an endogenous locus in living cells, Jos Meeussen, NKI (15’ + 5’, abstract 08)

12:10 - The Med13 intrinsically disordered region mediates Cdk8 recruitment and function via different mechanisms, Francois Robert, Institut de recherches cliniques de Montreal (15’ + 5’, abstract 09)

12:30 - Flash talks, 2 min + 2 slides per poster presenter

13:15 – Lunch (restaurant + outside), Meet speakers over lunch for further discussion

Session 3 (chair Tineke Lenstra)

15:00 - Structural basis for lysine-specific acetylation of nucleosomes
Sebastian Eustermann, EMBL (25’ + 5’, abstract 10)

15:30 - A non-canonical bromodomain-DNA interaction drives RSC-chromatin remodelling at polyA-rich promoters, Jerome Govin, Institute of Advanced Biosciences (15’ + 5’, abstract 11)

15:50 - Chromatin tethering by the trithorax homologous, MLL2, during the ESC naive to primed transition, Adrian Stewart, Technische Universität Dresden (15’ + 5’, abstract 12)

16:10 - Transcriptional control of transposable elements in the unicellular eukaryote Paramecium
Sandra Duharcourt, Institut Jacques Monod (25’ + 5’, abstract 13)

16:40 - Coffee break

17:10 - Novel players in chromatin, Robert Schneider, Helmholtz Zentrum München (25’ + 5’, abstract 14)

17:40 - The Ran-binding protein Mog1: a novel key regulator of histone modification and transcriptional elongation, Joan Serrano Quílez, IBV-CSIC (15’ + 5’, abstract 15)

18:00 - Cooperativity between two essential coregulators, Mediator and RSC chromatin remodelling complex, in transcription and chromatin organisation, Julie Soutourina, I2BC (15’ + 5’, abstract 16)

18:20 - Short break

18:30 – Keynote: How Transcription Circuits Evolve and Produce Phenotypic Novelty
Sandy Johnson, UCSF (abstract 17)

19:30 – Dinner (restaurant), Meet speakers over dinner for further discussion
20:30 - Poster session, 20:30-21:30 Odd numbers, 21:30-22:30 Even numbers

23:00 - End of session

Wednesday, 18 June 2025

from 8:00 – Breakfast (restaurant)

Session 4 (chair Robert Schneider)

09:00 - Human RNA polymerase II is maintained in excess for robust transcriptional homeostasis
Alexander Gillis, University of New South Wales (15’ + 5’, abstract 18)

09:20 - Gene-specific transcript buffering revealed by perturbation of co-activator complexes
Manuel Mendoza, IGBMC (15’ + 5’, abstract 19)

09:40 - Repressive transcription - when RNAPII elongation inhibits initiation
Sebastian Marquardt, Lund University (15’ + 5’, abstract 20)

10:00 - Meiotic Activation of Stress Response Pathways, Elçin Ünal, UC Berkeley (25’ + 5’, abstract 21)

10:30 - Coffee break

11:00 - Oxidative stress triggers a unique and transient dynamic transcriptional response
Lea Gregersen, University of Copenhagen (15’ + 5’, abstract 22)

11:20 - Transcriptional heterogeneity shapes stress-adaptive responses
Francesc Posas, IRB Barcelona (15’ + 5’, abstract 23)

11:40 - Molecular determinants for recognition of serotonylated H3Q5
Laura Pulido Cortés, Uniklinik Freiburg (15’ + 5’, abstract 24)

12:00 - Profiling transcriptional dynamics in host-pathogen interactions: Expanding the run-on sequencing toolbox from mosquitos to viruses, Femke Hout, Radboud UMC (15’ + 5’, abstract 25)

12:20 - Speed networking, Groups of randomly assigned participants will get together and introduce themselves and their science

13:00 - Lunch + Free time, Meet speakers over lunch for further discussion

13:15 - Excursion Girona (assemble at reception)
Excursion Girona leaves at 13.15 and returns at 17.30, A packed lunch will be provided

Session 5 (chair Martin Howard)

18:00 - Mechanisms of heterochromatin silencing – insight into genome evolution
Mo Motamedi, HMS (25’ + 5’, abstract 26)

18:30 - Exploring the rules of protein complex assembly and regulation
Alberto Elías Villalobos, Institute of Biomedicine of Seville (15’ + 5’, abstract 27)

18:50 – TSS switching dynamics of Ash2l controls development and proliferation, Folkert van Werven, Francis Crick Institute (15’ + 5’, abstract 28)

19:10 - Beyond phosphorylating Rpb1CTD, Hrr25 and Fcp1 modulate Rpb4 phosphorylation levels to regulate gene expression, Araceli Gonzalez-Jimenez, IBFG (15’ + 5’, abstract 29)

19:30 – Dinner, Meet speakers over dinner for further discussion
20:30 - Poster session, 20:30-21:30 Even numbers, 21:30-22:30 Odd numbers

23:00 - End of session

Thursday, 19 June 2025

from 8:00 – Breakfast (Restaurant)

Session 6 (chair Domenico Libri)

09:00 - Structural basis of the Integrator complex assembly and association with transcription factors
Michal Razew, EMBL (25’ + 5’, abstract 30)

09:30 - Quality control of RNA polymerase II at the promoter-proximal zone,

Roberta Cacioppo, MRC Laboratory of Molecular Biology (15’ + 5’, abstract 31)

09:50 - Structural and functional insights into the interactions between Fpt1 and the core tRNA transcription factors, Marianne Bakker, NKI (15’ + 5’, abstract 32)

10:10 - The role of INTS6/INTS6-like and INTS12 components of the integrator complex
Laura Corso, Walter and Eliza Hall Institute (15’ + 5’, abstract 33)

10:30 - Coffee break

11:00 - Real-time imaging of transcriptional feedback in nonsense-mediated mRNA decay
Hanae Sato, Kanazawa University (25’ + 5’, abstract 34)

11:30 - R-loop revisited through the magnifying glass of H-CRAC
Francisco Gutierrez, Institut de Génétique Moléculaire de Montpellier (15’ + 5’, abstract 35)

11:50 - Chromatin dynamics during spermiogenesis and regeneration in the Gryllus bimaculatus
Guillermo Orsi, Institute for Advanced Biosciences (15’ + 5’, abstract 36)

12:10 - G-quadruplexes are promoter elements controlling chromatin opening
Cyril Esnault, Institut de Génétique Moléculaire de Montpellier (15’ + 5’, abstract 37)

12:30 - Systematic two-hybrid screening uncovers a novel crosstalk between lysine and arginine methylation and identifies new functions for COMPASS, Vincent Geli, IRCAN (15’ + 5’, abstract 38)

13:00 – Lunch (restaurant + outside), Meet speakers over lunch for further discussion

Session 7 (chair Sebastian Eustermann)

15:00 - Promoter-proximal pausing and the transition to transcript elongation
Jesper Svejstrup, University of Copenhagen (25’ + 5’, abstract 39)

15:30 - mRNA poly(A) tail length is controlled by a kinetic ruler
Matti Turtola, University of Turku (15’ + 5’, abstract 40)

15:50 - SCAF1 directs neuronal differentiation through regulation of co-transcriptional processing
Smaragda Kompocholi, University of Copenhagen (15’ + 5’, abstract 41)

16:10 - Molecular details of Nrd1-Nab3 heterodimerization,

Jose Manuel Pérez Cañadillas, CSIC (15’ + 5’, abstract 42)

16:30 - Coffee break

17:00 – Lidia Vasilieva, University of Oxford (25’ + 5’, abstract 43)

17:30 - Characterisation of G4 binders in transcription regulation, Soumya Bouchouika, IGMM (15’ + 5’, abstract 44)

17:50 - Transcription elongation directionality hinders interference by antisense transcription
Alexandros Minakakis, Institut de Génétique Moléculaire de Montpellier (15’ + 5’, abstract 45)

18:10 - A tale of helicases, transcription termination and neurodegeneration,

Odil Porrua, Institut de Génétique Moléculaire de Montpellier (25’ + 5’, abstract 46)

18:40 - End of session

19:30 - Banquet & party (Salon Goya), Announcement of the poster prize

Friday, 20 June 2025

from 8:00 – Breakfast (Restaurant)

Session 8 (chair Odil Porrua)

09:30 - Fidelity in lineage determination and inducible gene expression in macrophages
Francesco Gualdrini, European Institute of Oncology (25’ + 5’, abstract 47)

10:00 - Alternative transcription termination sites usage in Cryptococcus neoformans
Jessie Colin, Institut Pasteur (15’ + 5’, abstract 48)

10:20 - FOXO – a transcription factor involved in the PRC1 tumor suppressor function
Ana-Maria Popmihaylova, Institute of Human Genetics (15’ + 5’, abstract 49)

10:40 - mRNA imprinting as means by which transcription controls the fate of its transcripts
Mordechai Choder, Technion – Haifa (15’ + 5’, abstract 50)

11:00 - Future of the workshop and closing remarks

11:10 - End of session

11:15 - Departure